Nerve Damage

Since FDA approved rhBMP-2 for treating degenerative disc disease, surgeons have expanded its use for other off-label procedures resulting in an increasing number of complications.  Among the complications are neurological complications that were not reported during the early application of rhBMP-2.  Early work indicated little morbidity on neurological tissues.  In-vivo studies indicated that rhBMP-2 triggers signaling response in nerve cells within the spinal cord and peripheral ganglia.  Preclinical studies indicated that rhBMP-2 could trigger significant inflammation and morphologic changes within these tissues that could be detrimental to neurologic recovery.  Certain other reports have demonstrated penetration of rhBMP-2 activates a signaling cascade in all major central nervous system cell types.

If you or someone you know suffered painful injuries after being implanted with a Medtronic Infuse Bone Graft device, you may have valuable legal rights. We’re here to answer any questions you may have. For a free case review fill out our online form to the right or call our office at 1 (855) 444-3713.